Journal of Aging Science

INSERM U1151 CNRS UMR8253 Institut Necker-Enfants Malades (INEM), Paris, France

Biography

Gérard Friedlander is associated as one of the members of Department of Medicine, University of Paris of city Paris located in France. Also working in INSERM U1151 CNRS UMR8253 Institut Necker-Enfants Malades (INEM), Paris, France.

Publications

• Review Article   
  Healthy Aging Biology, Powerful Insight from the Long-Lived Naked Mole-Rat
  Author(s): Frédéric Saldmann, Mélanie Viltard*, Christine Leroy, Patrice Codogno and Gérard Friedlander
  
  The naked mole-rat, Heterocephalus glaber, is the longest-lived rodent known with a lifespan in captivity >30 years, 10 times longer than mice, a comparable size rodent. In addition to a particularly long life, it exhibits exceptional resistance to many age-related diseases: cancer, cardiovascular, neurodegenerative, and metabolic diseases. It resists many forms of stress: hypoxia, oxidative stress, and strikingly maintains adequate body composition, fertility, bone quality, and mineral density throughout their long life. The naked mole-rat is a non-traditional animal model that defies the law governing the processes of aging and mortality and provides a powerful tool for the discovery of endogenous molecular anti-aging pathways. Over the past decades, much possible resistance and anti-aging mechanisms have been discovered. These include exclusive physiologica.. View more»
  

  DOI: 10.35248/2329-8847.21.9.258

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