Journal of Aging Science

Service de Médecine Vasculaire, Hôpital Européen Georges Pompidou, Assistance Publique-Hôpitaux de Paris, Paris, France

Biography

Christine Leroy is from the INSERM U1151-CNRS UMR8253, University Paris Descartes, and Functional Explorations Service, Hospital Necker-Enfants Malades in city of paris of country france

Publications

• Review Article   
  Healthy Aging Biology, Powerful Insight from the Long-Lived Naked Mole-Rat
  Author(s): Frédéric Saldmann, Mélanie Viltard*, Christine Leroy, Patrice Codogno and Gérard Friedlander
  
  The naked mole-rat, Heterocephalus glaber, is the longest-lived rodent known with a lifespan in captivity >30 years, 10 times longer than mice, a comparable size rodent. In addition to a particularly long life, it exhibits exceptional resistance to many age-related diseases: cancer, cardiovascular, neurodegenerative, and metabolic diseases. It resists many forms of stress: hypoxia, oxidative stress, and strikingly maintains adequate body composition, fertility, bone quality, and mineral density throughout their long life. The naked mole-rat is a non-traditional animal model that defies the law governing the processes of aging and mortality and provides a powerful tool for the discovery of endogenous molecular anti-aging pathways. Over the past decades, much possible resistance and anti-aging mechanisms have been discovered. These include exclusive physiologica.. View more»
  

  DOI: 10.35248/2329-8847.21.9.258

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