Department of Biological Sciences, El Paso, Texas 79968, USA
Watts DM is currently working as a Professor in the Department of Vaccines. His research interests includes Vaccines. He has successfully completed his Administrative responsibilities. He has authored of many research articles/books related to Vaccines
Research Article
Assessment of the Immunogenicity of a Novel Live Recombinant Rift Valley Fever arMP-
12ΔNSm21/384 Vaccine Candidate Following Intranasal Vaccination of Goats, Sheep
and Calves in Tanzania
Author(s): Nyundo S., Adamson E.K., Rowland J., Palermo P.M., Salekwa L., Matiko M.K., Bettinger G.E., Wambura P., Morrill J.C., Sullivan T.R. and Watts D.M.*
Background: Rift Valley fever virus (RVFV) is an arbovirus that causes morbidity and mortality in livestock and
humans throughout Africa and in the Arabian Peninsula. Vaccines are effective for the prevention of Rift Valley
fever (RVF) disease, but new and improved vaccines are needed to improve the safety of available vaccines. Also, non-invasive
needle free vaccine delivery routes should be evaluated as an alternative for invasive routes of vaccination.
Objective: The aim of this proof of concept study was to evaluate the safety and immunogenicity of a novel live
attenuated recombinant RVFV arMP-12ΔNSm21/384 vaccine candidate following intranasal vaccination of goats,
calves, and sheep in Tanzania.
Methods: Healthy, 6-9 months old breeds of African sheep (Ovis aeris), goats (Capra aegagrus) and z.. View more»