Journal of Vaccines & Vaccination

Department of Microbiology, Parasitology and Biotechnology, College of Veterinary and Medical sciences, Sokoine University of Agriculture, Morogoro, Tanzania

Publications

• Research Article   
  Assessment of the Immunogenicity of a Novel Live Recombinant Rift Valley Fever arMP- 12ΔNSm21/384 Vaccine Candidate Following Intranasal Vaccination of Goats, Sheep and Calves in Tanzania
  Author(s): Nyundo S., Adamson E.K., Rowland J., Palermo P.M., Salekwa L., Matiko M.K., Bettinger G.E., Wambura P., Morrill J.C., Sullivan T.R. and Watts D.M.*
  
  Background: Rift Valley fever virus (RVFV) is an arbovirus that causes morbidity and mortality in livestock and humans throughout Africa and in the Arabian Peninsula. Vaccines are effective for the prevention of Rift Valley fever (RVF) disease, but new and improved vaccines are needed to improve the safety of available vaccines. Also, non-invasive needle free vaccine delivery routes should be evaluated as an alternative for invasive routes of vaccination. Objective: The aim of this proof of concept study was to evaluate the safety and immunogenicity of a novel live attenuated recombinant RVFV arMP-12ΔNSm21/384 vaccine candidate following intranasal vaccination of goats, calves, and sheep in Tanzania. Methods: Healthy, 6-9 months old breeds of African sheep (Ovis aeris), goats (Capra aegagrus) and z.. View more»
  

  DOI: 10.35248/2157-7560.20.S5:002

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