Journal of Nanomedicine & Nanotechnology

Department of Medicine, Louisville, KY, 40202, USA

Biography

Dr. Jon Klein, M.D., Ph.D., is the James Graham Brown Foundation Chair in Proteomics -- the first such chair in America dedicated to the rapidly expanding field. He is also a professor in the Department of Medicine and the Departments of Biochemistry and Molecular Biology and Microbiology and Immunology, as well as director of U of L’s Core Proteomics Laboratory.

Publications

• Research   
  Plasma and Serum Proteins Bound to Nanoceria: Insights into Pathways by which Nanoceria may Exert Its Beneficial and Deleterious Effects In Vivo
  Author(s): Allan Butterfield D*, Binghui Wang, Peng Wu, Sarita S. Hardas, Jason M. Unrine, Eric A. Grulke, Jian Cai, Jon B. Klein, William M. Pierce, Robert A. Yokel and Rukhsana Sultana
  
  Nanoceria (CeO2, cerium oxide nanoparticles) is proposed as a therapeutic for multiple disorders. In blood, nanoceria becomes protein-coated, changing its surface properties to yield a different presentation to cells. There is little information on the interaction of nanoceria with blood proteins. The current study is the first to report the proteomics identification of plasma and serum proteins adsorbed to nanoceria. The results identify a number of plasma and serum proteins interacting with nanoceria, proteins whose normal activities regulate numerous cell functions: antioxidant/detoxification, energy regulation, lipoproteins, signaling, complement, immune function, coagulation, iron homeostasis, proteolysis, inflammation, protein folding, protease inhibition, adhesion, protein/RNA degradation, and hormonal. The principal implications of this study are: 1) The protein cor.. View more»
  

  DOI: 10.35248/2157-7439.20.11.546

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