Journal of Nanomedicine & Nanotechnology

Professor, Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA

Biography

Dr. Butterfield is the UK Alumni Association Endowed Professor of Biological Chemistry, director of the Redox Metabolism Core of the Markey Cancer Center, and faculty in both the Spinal Cord and Brain Injury Research Center and the Sanders-Brown Center on Aging. His research focuses on free radical oxidative stress in aging and age-related neurodegenerative disorders, particularly Alzheimer's disease.

Publications

• Research   
  Plasma and Serum Proteins Bound to Nanoceria: Insights into Pathways by which Nanoceria may Exert Its Beneficial and Deleterious Effects In Vivo
  Author(s): Allan Butterfield D*, Binghui Wang, Peng Wu, Sarita S. Hardas, Jason M. Unrine, Eric A. Grulke, Jian Cai, Jon B. Klein, William M. Pierce, Robert A. Yokel and Rukhsana Sultana
  
  Nanoceria (CeO2, cerium oxide nanoparticles) is proposed as a therapeutic for multiple disorders. In blood, nanoceria becomes protein-coated, changing its surface properties to yield a different presentation to cells. There is little information on the interaction of nanoceria with blood proteins. The current study is the first to report the proteomics identification of plasma and serum proteins adsorbed to nanoceria. The results identify a number of plasma and serum proteins interacting with nanoceria, proteins whose normal activities regulate numerous cell functions: antioxidant/detoxification, energy regulation, lipoproteins, signaling, complement, immune function, coagulation, iron homeostasis, proteolysis, inflammation, protein folding, protease inhibition, adhesion, protein/RNA degradation, and hormonal. The principal implications of this study are: 1) The protein cor.. View more»
  

  DOI: 10.35248/2157-7439.20.11.546

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