Journal of Nanomedicine & Nanotechnology

Department of Chemical and Materials Engineering, University of Kentucky, Lexington, KY 40506, USA

Biography

Dr. Eric Grulke, professor of chemical engineering and former director of the engineering electron microscopy center. He began teaching at UK in 1993, after spending 15 years teaching chemical engineering and serving in administrative roles at Michigan State University. He was hired into the Department of Chemical and Materials Engineering as professor and chair and later served as associate dean of research and graduate studies from 2003-2015.

Publications

• Research   
  Plasma and Serum Proteins Bound to Nanoceria: Insights into Pathways by which Nanoceria may Exert Its Beneficial and Deleterious Effects In Vivo
  Author(s): Allan Butterfield D*, Binghui Wang, Peng Wu, Sarita S. Hardas, Jason M. Unrine, Eric A. Grulke, Jian Cai, Jon B. Klein, William M. Pierce, Robert A. Yokel and Rukhsana Sultana
  
  Nanoceria (CeO2, cerium oxide nanoparticles) is proposed as a therapeutic for multiple disorders. In blood, nanoceria becomes protein-coated, changing its surface properties to yield a different presentation to cells. There is little information on the interaction of nanoceria with blood proteins. The current study is the first to report the proteomics identification of plasma and serum proteins adsorbed to nanoceria. The results identify a number of plasma and serum proteins interacting with nanoceria, proteins whose normal activities regulate numerous cell functions: antioxidant/detoxification, energy regulation, lipoproteins, signaling, complement, immune function, coagulation, iron homeostasis, proteolysis, inflammation, protein folding, protease inhibition, adhesion, protein/RNA degradation, and hormonal. The principal implications of this study are: 1) The protein cor.. View more»
  

  DOI: 10.35248/2157-7439.20.11.546

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