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Youssouf Kaboré
Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso
Biography
Youssouf Kaboré aassociated with Centre National de Recherche et de Formation sur le Paludisme (CNRFP) · Molecular Epidemiology/ Genetics. His research interests lie in the area of Malaria, Medicine, Incidence, Pediatrics, Adverse effect, Randomized controlled trial, Plasmodium falciparum, Amodiaquine, Sulfadoxine, Malaria vaccine, Placebo-controlled study, Clinical endpoint, Immunology, Population, Biology, Environmental health, Vaccination, Internal medicine, Reactogenicity, Immunogenicity
Publications
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Original Research Article
Seroreactivity of Populations Living in Endemic Area of Burkina Faso to Plasmodium falciparum Alpha-Helical Coiled Coil Proteins Motifs by Protein Microarray
Author(s): Oumarou Ouédraogo*, Luisa Nunziangeli, Edith C. Bougouma, Youssouf Kaboré, Amidou Diarra, Blami Koté, Alfred B. Tiono, Giampietro Corradin, Valentina Mangano, David Modiano, Yves Traoré, Sodiomon B. Sirima, Roberta Spaccapelo and Issa Nébié
The naturally acquired immunity is one of the models of immunity that is exploited for malaria antigens discovery. We have used multiplex protein microarrays of 92 P. falciparum alpha-helical coiled coil protein motifs to screen plasma samples obtained from 1113 children and adults belonging to three sympatric ethnic groups from malaria endemic area of Burkina Faso. We have investigated the influence of some factors such as age, ethnicity, hemoglobin genotype and sex on the antigens reactivity and the IgG antibody level. We also investigated specifically, the influence of the factors mentioned above on the 36 antigens with the highest antibody prevalence and intensity. As expected, the findings of the study confirmed the positive correlation between age, antigens reactivity and IgG antibody level. Except for three antigens (MSP2_3D7, MR260, and As182.20), the IgG level was hi.. View more»