Journal of Carcinogenesis & Mutagenesis

Dr, Division of Applied Life Science, Graduate School of Engineering, Sojo University, Kumamoto, Japan

Biography

Yoko Matsumoto is a Professor of Department of Life Sciences at Sojo University, Japan. She received her PhD in Pharmacy from Kyushu University, Japan. She was a Visiting Researcher in Colorado University at Boulder with Prof. Tom Cech. She has received Outstanding Female Researcher Award from the Society of Chemical Engineering, Japan. She is one of Director for Japan Nanomedicine Society and Councilor for Japanese Association for Molecular Target Therapy of Cancer. Her current research interest focuses on trehalose liposomes for therapeutic applications. She has published more than 120 original papers.

Publications

• Research Article   
  Novel Therapy with Hybrid Liposomes for Orthotopic Graft Mouse Models of Glioblastoma
  Author(s): Keiji Kuwabara, Hideaki Ichihara and Yoko Matsumoto*
  
  Hybrid Liposomes (HL25) composed of 90 mol% L-a-Dimyristoylphosphatidylcholine (DMPC) and 10 mol% polyoxyethylene(25) dodecyl ethers (C12(EO)25) were found to fuse and accumulate in the cell membranes of human brain tumor, glioblastoma, (U-87MG) cells and inhibit their growth. HL25 induced apoptosis in U-87MG cells via the release of AIF under a caspase-independent pathway. HL25 inhibited tumor enlargement in orthotopic graft mouse models of glioblastoma after crossing the blood-brain barrier. .. View more»
  

  DOI: 10.35248/2157-2518.21.12.360

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