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Hideaki Ichihara
Division of Applied Life Science, Graduate School of Engineering, Sojo University, Kumamoto, Japan
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Research Article
Novel Therapy with Hybrid Liposomes for Orthotopic Graft Mouse Models of Glioblastoma
Author(s): Keiji Kuwabara, Hideaki Ichihara and Yoko Matsumoto*
Hybrid Liposomes (HL25) composed of 90 mol% L-a-Dimyristoylphosphatidylcholine (DMPC) and 10 mol% polyoxyethylene(25) dodecyl ethers (C12(EO)25) were found to fuse and accumulate in the cell membranes of human brain tumor, glioblastoma, (U-87MG) cells and inhibit their growth. HL25 induced apoptosis in U-87MG cells via the release of AIF under a caspase-independent pathway. HL25 inhibited tumor enlargement in orthotopic graft mouse models of glioblastoma after crossing the blood-brain barrier. .. View more»