Journal of Biomolecular Research & Therapeutics

Department of Geriatrics, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China

Biography

Ying Shen is currently an Associate Professor in School of Software Engineering, Tongji University, Shanghai, PR China. She received her PhD and Master degree from City University of Hong Kong and Shanghai Jiaotong University respectively.

Publications

• Research   
  Molecular Mechanisms of Angiotensin-converting Enzyme Inhibitory Peptide LAP Activity on Apoptosis of Vascular Smooth Muscle
  Author(s): Yi Shen, Hong Fang*, Abdurrahman Omer Cavdar and Chi Liu
  
  We observe the expression levels of apoptotic cells, Bcl-2/Bax and caspase-9 on abdominal aorta of spontaneously hypertensive rats (SHRs) to investigate impact and mechanisms of angiotensin converting enzyme inhibitory peptide LAP in apoptosis of vascular smooth muscle cell. A total of 20 male SHRs were studied to detect apoptotic cells and the expression of apoptosis-related proteins (Bcl-2, Bax, caspase-9). The index of apoptotic cells in LAP group was significantly lower compared to the control group. The expression of Bcl-2 in the LAP group was significantly higher than the control group. However, the levels of Bax and caspase-9 expression in the LAP group were significantly lower compared to the control group. The apoptosis index was negatively correlated with Bcl-2 and positively correlated with Bax/caspase-9. Similarly, the inflammation markers in LAP group were significantly l.. View more»
  

  DOI: 10.35248/2167-7956.19.8.178

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