Journal of Biomolecular Research & Therapeutics

Department of Cardiology, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China

Biography

He is affiliated to Department of Cardiology, Tongji Hospital, School of Medicine, Tongji University, Shanghai  China . He is a recipient of many awards and grants for his valuable contributions and discoveries in major area of subject research. His international experience includes various programs, contributions and participation in different countries for diverse fields of study.  His research interests reflect in his wide range of publications in various national and international journals. 

Publications

• Research   
  Molecular Mechanisms of Angiotensin-converting Enzyme Inhibitory Peptide LAP Activity on Apoptosis of Vascular Smooth Muscle
  Author(s): Yi Shen, Hong Fang*, Abdurrahman Omer Cavdar and Chi Liu
  
  We observe the expression levels of apoptotic cells, Bcl-2/Bax and caspase-9 on abdominal aorta of spontaneously hypertensive rats (SHRs) to investigate impact and mechanisms of angiotensin converting enzyme inhibitory peptide LAP in apoptosis of vascular smooth muscle cell. A total of 20 male SHRs were studied to detect apoptotic cells and the expression of apoptosis-related proteins (Bcl-2, Bax, caspase-9). The index of apoptotic cells in LAP group was significantly lower compared to the control group. The expression of Bcl-2 in the LAP group was significantly higher than the control group. However, the levels of Bax and caspase-9 expression in the LAP group were significantly lower compared to the control group. The apoptosis index was negatively correlated with Bcl-2 and positively correlated with Bax/caspase-9. Similarly, the inflammation markers in LAP group were significantly l.. View more»
  

  DOI: 10.35248/2167-7956.19.8.178

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