Journal of Nanomedicine & Nanotechnology

Biorefining and Advanced Materials Research Centre, Scotland’s Rural College (SRUC), Kings Buildings, Edinburgh EH9 3JG, UK

Publications

• Research   
  Hyaluronic Acid Coated and Poly-L-lysine Functionalized Graphene Quantum Dots for CD44 targeted Anti-Cancer Drug Delivery against Osteosarcoma
  Author(s): Khushboo Dutta, Saty Decakash Ahirwar, Vijay Kumar Thakur, Piyush Kumar Gupta and Sunita Nayak*
  
  Due to less toxicity and strong fluorescence properties, graphene quantum dots, i.e., GQDs have been shown to play a promising role in drug delivery applications. Hyaluronic acid (HA), used as a targeting ligand in this drug delivery system, is a polysaccharide which interacts with the hyaluronan receptor that is, CD44. Poly-L-lysine (PLL), containing amine groups, can be efficiently conjugated to the hydrophobic substances with carboxyl moieties. In this study, a novel drug delivery system composed of GQD coated with HA and coupled with PLL has been designed as a potent theranostic candidate for osteosarcoma therapy for the targeted delivery of DNA intercalating drug doxorubicin (DOX) to cancer cells. The characterization studies for morphology, structural analysis, and optical properties were evaluated. The drug loading, drug release profile, and anti-cancer eff.. View more»
  

  DOI: 10.35248/2157-7439.22.13.651.

  Abstract HTML PDF