Pharmaceutica Analytica Acta

Drug Delivery System Excellence Centre, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Thailand

Biography

Teerapol Srichana works in the Faculty of Pharmaceutical Sciences, Prince of Songkla University, Thailand. The respected author has specialization in the field of Pharmacy

Publications

• Research Article   
  Development and Evaluation of Curcumin Floating Tablets
  Author(s): Kishor A. Bellad, Basavaraj K. Nanjwade*, Arindam Basu Sarkar, Teerapol Srichana and Roopali M. Shetake
  
  In the present study, curcumin an anti-inflammatory agent, was first complexed with the soluplus by hot melt extrusion machine to enhance the solubility of curcumin and was formulated into floating tablets by direct compression method. Tablets were formulated using various grades of Hydroxypropyl methylcellulose (HPMC) polymers and sodium bicarbonate as gas generating agent. Preformulation and micromeritic studies were performed. The floating tablets were evaluated for their physico-chemical properties, in-vitro release, in-vivo floating property, pharmacokinetic and stability studies. Formulations were found uniform with respect to thickness (5.11 to 5.27 mm) and hardness (4.4 to 4.8 kg/cm2). The friability (0.27 to 0.53 %), weight variation (1.28-1.89%) and Drug content (97.84 to 99.46 %). The order of swelling index of HPMC was found to be K100M > K15M > K.. View more»
  

  DOI: 10.35248/2153-2435.20.11.622

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