Pharmaceutica Analytica Acta

Department of Pharmaceutics, KLE College of Pharmacy, Karnataka, India

Biography

Kishor A. Bellad works in the department of pharmaceutics, in KLE College of pharmacy, is located in  Karnataka, India. And author has specialization in the field of pharmaceutics.

Publications

• Research Article   
  Development and Evaluation of Curcumin Floating Tablets
  Author(s): Kishor A. Bellad, Basavaraj K. Nanjwade*, Arindam Basu Sarkar, Teerapol Srichana and Roopali M. Shetake
  
  In the present study, curcumin an anti-inflammatory agent, was first complexed with the soluplus by hot melt extrusion machine to enhance the solubility of curcumin and was formulated into floating tablets by direct compression method. Tablets were formulated using various grades of Hydroxypropyl methylcellulose (HPMC) polymers and sodium bicarbonate as gas generating agent. Preformulation and micromeritic studies were performed. The floating tablets were evaluated for their physico-chemical properties, in-vitro release, in-vivo floating property, pharmacokinetic and stability studies. Formulations were found uniform with respect to thickness (5.11 to 5.27 mm) and hardness (4.4 to 4.8 kg/cm2). The friability (0.27 to 0.53 %), weight variation (1.28-1.89%) and Drug content (97.84 to 99.46 %). The order of swelling index of HPMC was found to be K100M > K15M > K.. View more»
  

  DOI: 10.35248/2153-2435.20.11.622

  Abstract HTML PDF