Department of General Biology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil
Graduated in Biological Sciences (2006), Master in Genetics (2009) and Graduated in Law (2014) from the Federal University of Minas Gerais (UFMG). He holds a Ph.D. in Bioinformatics from UFMG (2019), with a sandwich internship (2018-2019) at the University of Michigan (USA). Has experience in Genetics, Genomics and Bioinformatics. He is currently responsible for the Genomics Center of the Multiuser Laboratories Center (CELAM) at UFMG.
Research Article
Insights of How Lung Microbiome can Contribute to COVID-19 Severity in Intensive Care Unit Patients
Author(s): Fabíola Marques de Carvalho, Leandro Nascimento Lemos, Luciane Prioli Ciapina, Rennan Garcias Moreira, Alexandra Gerber, Ana Paula C. Guimarães, Tatiani Fereguetti, Virgínia Antunes de Andrade Zambelli, Renata Avila, Tailah Bernardo de Almeida, Jheimson da Silva Lima, Shana Priscila C. Barroso, Mauro Martins Teixeira, Renan Pedra Souza, Cynthia Chester Cardoso, Renato Santana Aguiar and Ana Tereza R. de Vasconcelos*
Objectives: Secondary bacterial and fungal infections are associated with respiratory viral infections and invasive
mechanical ventilation. Microbiome influence on COVID-19 severity in patients admitted to intensive care units
(ICU) remains poorly understood. This work described the lung microbiota of Brazilian COVID-19 patients and
explored how microbial pathogens can contribute to Coronavirus disease 2019 clinical outcome.
Methods: Total DNA of bronchoalveolar lavage fluids from 21 Brazilian COVID-19 patients was extracted. All
patients were positive RT-PCR and admitted to intensive care units in two Brazilian centers. For metagenomic
analyses, sequenced reads were submitted to bioinformatic tools for taxonomic and functional inferences.
Results: We identified respiratory, nosocomial, and opportunistic pat.. View more»