Internal Medicine and ICU, Square Hospitals Ltd., Dhaka, Bangladesh
Raihan Rabbani is currently working at Internal Medicine and ICU, Square Hospitals Ltd., Dhaka, Bangladesh and his scientific research interests are Ventilation, Septic Shock, Mechanical Ventilation.
Research
Tigecycline in CR-Kp Associated VAP with High Dose vs. Conventional Dose: Adverse Events are the Key Superiority-determiner
Author(s): Md Jahidul Hasan*, Raihan Rabbani, Shihan Mahmud Redwanul Huq and Sitesh Chandra Bachar
Background: Multi-drug Resistant (MDR) pathogen Carbapenem-Resistance Klebsiella pneumonia (CR-Kp) associated Ventilator-Associated Pneumonia (VAP) is a serious infectious disease and tigecycline with high or conventional dose, is one of the last resort potential antibiotics for its treatment.
Objective: The major objective of this study was to evaluate the key role of adverse events in preferring the better dosing option of tigecycline.
Methods: Total 45 middle-aged MDR-CR-Kp associated VAP patients and treated with high (200 mg/day) and conventional dose (100 mg/day) of tigecycline (intravenous) distributed into two groups. Group-wise microbiological eradication rate, secondary infection rate, 30 days mortality rate and dose-related adverse events were analyzed and compared, accordingly.
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