Pharmaceutical Sciences, Roche Innovation Center Basel, Roche Pharma Research and Early Development, Basel, Switzerland
Mathias Leddin is currently working as a Professor in the Department of Medicine. Mathias Leddin has authored of many research articles/books related to Medicine.Mathias Leddin is serving as an editorial member and reviewer of several international reputed journals. Mathias Leddin has successfully completed his Administrative responsibilities and research interests includes Medicine.
Research Article
A COVID-19 Transmission Model Informing Medication Development and Supply Chain Needs
Author(s): Annabelle Lemenuel-Diot*, Barry Clinch, Aeron C. Hurt, Paul Boutry, Johann Laurent, Mathias Leddin, Stefan Frings and Jean Eric Charoin
Objective: We present a country-specific, modified Susceptible, Exposed, Infectious, and Removed (SEIR) model
of SARS-CoV-2 transmission aiming to provide accurate prediction of COVID-19 cases to optimize clinical trial
recruitment, inform mitigation strategies, and facilitate rapid medication development.
Methods: Epidemiological data from more than 170 countries were obtained from the Johns Hopkins University
COVID-19 Dashboard. Intercountry differences in initial exposure, cultural/environmental factors, and stringency
of mitigation strategies were incorporated. Asymptomatic patients and “super-spreaders” were also factored into our
model. Simulations were limited to a period of 2 months considering that the effects of certain parameters (e.g.
seasonality of virus transmission, wearing of face masks, and deploy.. View more»