Journal of Clinical & Experimental Pharmacology

Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, University of Tripoli, Tripoli, Libya

Publications

• Research Article   
  The effect of Tamoxifen on Indomethacin induced hepato-nephrotoxicity in rats
  Author(s): Malak M Eljafari*, Aisha M Dugani, Soad A Treesh and Amal Musa
  
  Background: Indomethacin is a widely prescribed nonsteroidal anti-inflammatory drug (NSAID) with a known hepato-renal toxicity. Tamoxifen is the treatment of choice for women with estrogen receptor-positive breast cancer. Aim: This study was aimed to investigate the effects of tamoxifen (TAM) on renal toxicity and hepatic damage induced by indomethacin (IND) in rats. Methods: Hepato-renal toxicity was induced in female Wistar rats by a single dose of IND (150 mg/kg) administered by gavage. TAM pretreatment involved Subcutaneous (SC) administration of the drug in a dose of 0.5 mg/kg/day for 5 consecutive days. Assessment of liver and kidney toxicities was based on determination of the activity of liver enzymes sGPT, sGOT, ALP, serum urea and serum creatinine as well as the ratio of liver and kidneys weight to total body.. View more»
  

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