Journal of Clinical & Experimental Pharmacology

Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, University of Tripoli, Tripoli, Libya

Biography

Aisha Dugani is one of the staff members at the department of pharmacology and clinical pharmacy. She is working as a full professor since 2008-07-13. She teaches several subjects in her major and has several puplications in esteemed international Journals in the field of her interest.

Publications

• Research Article   
  The effect of Tamoxifen on Indomethacin induced hepato-nephrotoxicity in rats
  Author(s): Malak M Eljafari*, Aisha M Dugani, Soad A Treesh and Amal Musa
  
  Background: Indomethacin is a widely prescribed nonsteroidal anti-inflammatory drug (NSAID) with a known hepato-renal toxicity. Tamoxifen is the treatment of choice for women with estrogen receptor-positive breast cancer. Aim: This study was aimed to investigate the effects of tamoxifen (TAM) on renal toxicity and hepatic damage induced by indomethacin (IND) in rats. Methods: Hepato-renal toxicity was induced in female Wistar rats by a single dose of IND (150 mg/kg) administered by gavage. TAM pretreatment involved Subcutaneous (SC) administration of the drug in a dose of 0.5 mg/kg/day for 5 consecutive days. Assessment of liver and kidney toxicities was based on determination of the activity of liver enzymes sGPT, sGOT, ALP, serum urea and serum creatinine as well as the ratio of liver and kidneys weight to total body.. View more»
  

  Abstract HTML PDF