Journal of Biomolecular Research & Therapeutics

Department of Gastroenterology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China

Biography

Lu M is currently working at Department of Gastroenterology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. He is a member of a number of organisations and is the author of numerous books and articles, including Diagnosis and Treatment of Rosacea, Demodykozu, Dermatitis Peryoralnoho Considering Factors Commonly Occurring Pathogenesis and Clinical Course Features Dermatoses, Skin and Venereal Diseases, Quality of Life in Dermatological Patients.

Publications

• Research   
  Hepatoprotective Effect of S-ademetionine in the treatment of Intrahepatic Cholestasis through Farnesoid X Receptor Mechanism in Rats
  Author(s): Mao H*, Jin D, Lu M, Jin S and Huang Y
  
  S-ademetionine (AdoMet) had been extensively studied in several clinical studies to treat Intrahepatic Cholestasis (IHC). The exact mechanism of action of AdoMet to regulator bile acid is unknown. Farnesoid X Receptor (FXR), a multifunctional nuclear receptor, plays vital roles in metabolism of bile acid. This study aims to investigate the mechanism of action of S-ademetionine in FXR to treat IHC. The IHC Sprague Dawley (SD) rat model was developed by administering Alpha Naphthyl Isothiocyanate (ANIT, 50 mg/kg). FXR excitant GW4064 (3 mg/kg) was used as a control to observe the impact of AdoMet (60 mg/kg) on the changes in serum direct levels in these rats. The hepatic histology between the HE staining contrast groups was performed using the Q-PCR to test FXR and the in situ hybridization was used to test the changes of bile salt export pump (Bsep), multidrug resistance-assoc.. View more»
  

  DOI: 10.35248/2167-7956.19.8.176

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