Journal of Biomolecular Research & Therapeutics

Department of Gastroenterology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China

Biography

Jin S is recently working at Department of Gastroenterology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. He has been a recipient of many award and grants. His international experience includes various programs, contributions and participation in different countries for diverse fields of study. His research interests reflect in his wide range of publications in various national and international journals.

Publications

• Research   
  Hepatoprotective Effect of S-ademetionine in the treatment of Intrahepatic Cholestasis through Farnesoid X Receptor Mechanism in Rats
  Author(s): Mao H*, Jin D, Lu M, Jin S and Huang Y
  
  S-ademetionine (AdoMet) had been extensively studied in several clinical studies to treat Intrahepatic Cholestasis (IHC). The exact mechanism of action of AdoMet to regulator bile acid is unknown. Farnesoid X Receptor (FXR), a multifunctional nuclear receptor, plays vital roles in metabolism of bile acid. This study aims to investigate the mechanism of action of S-ademetionine in FXR to treat IHC. The IHC Sprague Dawley (SD) rat model was developed by administering Alpha Naphthyl Isothiocyanate (ANIT, 50 mg/kg). FXR excitant GW4064 (3 mg/kg) was used as a control to observe the impact of AdoMet (60 mg/kg) on the changes in serum direct levels in these rats. The hepatic histology between the HE staining contrast groups was performed using the Q-PCR to test FXR and the in situ hybridization was used to test the changes of bile salt export pump (Bsep), multidrug resistance-assoc.. View more»
  

  DOI: 10.35248/2167-7956.19.8.176

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