Department of Clinical Affairs, Boston Heart Diagnostics/Eurofins, Framingham, MA, USA
Lihong He is currently working as a Professor in the Department of Medicine. Lihong He is serving as an editorial member and reviewer of several international reputed journals. Lihong He has successfully completed his Administrative responsibilities His research interests includes Medicine. Lihong He has authored of many research articles/books related to Medicine.
Research Article
Clinical Utility of Corona Virus Disease-19 Immunoglobulin G, M, Spike Protein, and Neutralizing Antibodies in Health, Disease and Post-Vaccination
Author(s): Ernst J. Schaefer, Florence Comite, Latha Dulipsingh, Maxine Lang, Jessica Jimison, Martin M. Grajower, Nathan E. Lebowitz, Andrew S. Geller, Margaret R. Diffenderfer, Lihong He, Gary Breton, Michael L. Dansinger, Ben Saida, Chong Yuan and R. Travis Wilkes
Objective: About 80% of corona virus disease-19 (COVID-19) deaths due to severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2) infection occur in subject’s ≥ 65 years of age, even though subjects in this age group
only account for about 10% of COVID-19 cases. Our objectives were to assess age effects and the clinical utility of
COVID-19 antibody levels in health, disease, and post-vaccination.
Methods: We measured serum SARS-CoV-2 immunoglobulin M (IgM), IgG and neutralizing antibodies using
immunoassay kits obtained from Diazyme (Poway, CA) and spike (S) protein antibodies using immunoassay kits
obtained from Roche Diagnostics (Indianapolis, IN).
Results: In 79,005 subjects, IgG and IgM levels were positive (≥1.0 arbitrary units [AU]/mL) in 5.29% and 3.25%
of subjects, respectively.. View more»