Journal of Pharmacovigilance

Department of Pharmacy, Shinshu University Hospital, 3-1-1 Asahi, Matsumoto, Japan

Biography

Dr.Kentaro Murai is an eminent researcher. Currently he is working in the Department of Pharmacy, Shinshu University Hospital,  Asahi, Matsumoto, Japan. He has also worked in the Department of Biochemical Pharmacology and Toxicology, Graduate School of Medicine, Shinshu University, Matsumoto, Japan. He has many publications. His area of expertise is Pharmacokinetics, Clinical Research, Pharmacovigilance,Pharmacokinetics.

Publications

• Research Article   
  Detecting Coadministered Drugs that Affect the Incidence of Long QT Syndrome Associated with Fluoroquinolone Antibiotics Using a Spontaneous Reporting System
  Author(s): Jun Matsuo, Satoshi Yamaori*, Kentaro Murai, Akira Mimura and Shigeru Ohmori
  
  Background: Fluoroquinolone antibiotics (FQs) are known to induce long QT syndrome (LQTS). However, the combination of FQ and non-FQ drugs that elevate the incidence of LQTS has not been extensively studied. Here, we analyzed concomitant drugs that influence the risk of FQ-induced LQTS using a spontaneous reporting system. Methods: We assessed adverse event reports in the Japanese Adverse Drug Event Report (JADER) database. The reporting odds ratio (ROR) and its 95% confidence interval (CI) were applied for signal detection. Furthermore, we evaluated the time-to-onset data for drug-related LQTS. Results: The single use of garenoxacin, moxifloxacin, and ciprofloxacin was significantly associated with LQTS with RORs (95% CIs) of 3.16 (2.24 – 4.44), 7.65 (5.29 – 11.07), and 1.98 (1.06 – 3.70), respectively. The concomitant use of garenoxacin and disopyrami.. View more»
  

  Abstract PDF