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Jun Matsuo
Department of Pharmacy, Shinshu University Hospital, 3-1-1 Asahi, Matsumoto, Japan
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Research Article
Detecting Coadministered Drugs that Affect the Incidence of Long QT Syndrome Associated with Fluoroquinolone Antibiotics Using a Spontaneous Reporting System
Author(s): Jun Matsuo, Satoshi Yamaori*, Kentaro Murai, Akira Mimura and Shigeru Ohmori
Background: Fluoroquinolone antibiotics (FQs) are known to induce long QT syndrome (LQTS). However, the combination of FQ and non-FQ drugs that elevate the incidence of LQTS has not been extensively studied. Here, we analyzed concomitant drugs that influence the risk of FQ-induced LQTS using a spontaneous reporting system. Methods: We assessed adverse event reports in the Japanese Adverse Drug Event Report (JADER) database. The reporting odds ratio (ROR) and its 95% confidence interval (CI) were applied for signal detection. Furthermore, we evaluated the time-to-onset data for drug-related LQTS. Results: The single use of garenoxacin, moxifloxacin, and ciprofloxacin was significantly associated with LQTS with RORs (95% CIs) of 3.16 (2.24 – 4.44), 7.65 (5.29 – 11.07), and 1.98 (1.06 – 3.70), respectively. The concomitant use of garenoxacin and disopyrami.. View more»