Journal of Vaccines & Vaccination

Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA

Biography

Dr. Jagannadha Sastry is a Professor in the Department of Immunology at UT MD Anderson Cancer Center in Houston and in the Department of Veterinary Sciences in Science Park. Over the past 25+ years, Dr. Sastry has conducted research in the broad areas of viral oncology and immunology focuses on understanding the biology, pathology and genetics of two viral diseases impacting human health: HPV-associated cancers and HIV-induced AIDS. The overall goal of his research is to develop procedures and reagents for prediction, treatment as well as prevention. 

Publications

• Research   
  SHIV Virus-Like Particles (VLPs) Vaccination Induces Partial Protection from SHIV Challenge in a Rhesus Macaque Model
  Author(s): Ethan Poteet, Phoebe Lewis, Zhiyin Yu, Changyi Chen, Guojun Yang, Pramod N Nehete, K Jagannadha Sastry, Gary Fujii and Qizhi Yao*
  
  Simian/Human immunodeficiency virus (SHIV) virus-like particles (VLPs) composed of SIV Gag, HIVsf162 gp120/ gp41 envelope, and human CD40L are whole pseudovirion vaccines capable of eliciting both humoral and cellular immunity. We immunized four rhesus macaques by intranasal prime and four sub-cheek boosts with VLPs adjuvanted with conjugatable adjuvant lipid vesicles containing monophosphoryl lipid A (MPLA), and compared their immune parameters to those in five unimmunized control macaques. Increased plasma antibody titers to SIV Gag were observed in all four immunized macaques and increased sf162 gp140 titers were observed in three of the four with one macaque (10-195) maintaining sustained anti-Env antibody levels. Compared to controls, a significant increase in memory B cells and CD4+ central memory T cells was detected in the immunized group. Among these, elevated Gagspecific CD1.. View more»
  

  Abstract PDF