Journal of Vaccines & Vaccination

Michael E DeBakey Department of Surgery, Division of Surgical Research, Baylor College of Medicine, Houston, Texas, USA

Biography

Changyi Chen is currently working as a Professor in the Department of Surgery. His research interests includes Medicine. He is serving as an editorial member and reviewer of several international reputed journals. He has successfully completed his Administrative responsibilities. He has authored of many research articles/books related to Medicine.

Publications

• Research   
  SHIV Virus-Like Particles (VLPs) Vaccination Induces Partial Protection from SHIV Challenge in a Rhesus Macaque Model
  Author(s): Ethan Poteet, Phoebe Lewis, Zhiyin Yu, Changyi Chen, Guojun Yang, Pramod N Nehete, K Jagannadha Sastry, Gary Fujii and Qizhi Yao*
  
  Simian/Human immunodeficiency virus (SHIV) virus-like particles (VLPs) composed of SIV Gag, HIVsf162 gp120/ gp41 envelope, and human CD40L are whole pseudovirion vaccines capable of eliciting both humoral and cellular immunity. We immunized four rhesus macaques by intranasal prime and four sub-cheek boosts with VLPs adjuvanted with conjugatable adjuvant lipid vesicles containing monophosphoryl lipid A (MPLA), and compared their immune parameters to those in five unimmunized control macaques. Increased plasma antibody titers to SIV Gag were observed in all four immunized macaques and increased sf162 gp140 titers were observed in three of the four with one macaque (10-195) maintaining sustained anti-Env antibody levels. Compared to controls, a significant increase in memory B cells and CD4+ central memory T cells was detected in the immunized group. Among these, elevated Gagspecific CD1.. View more»
  

  Abstract PDF