Journal of Nanomedicine & Nanotechnology

Abionic SA, Route de la Corniche 5, Epalinges, Switzerland

Biography

Dr. Fabien studied biology at the University of Lausanne before carrying out his PhD work that focused on molecular mechanisms of MALT1 function. After obtaining his PhD in 2009, Fabien joined Cytos Biotechnology as Group Leader in preclinical drug development and from 2012 the HES-SO as Research Scientist in the diagnostic unit.

Publications

• Research   
  Nanofluidics Drives Point-of-care Technology for on the Spot Protein Marker Analysis with Rapid Actionable Results
  Author(s): Laur�©anne Putallaz, Patrick van den Bogaard, Priscille Laub and Fabien Rebeaud*
  
  Protein sensing in a nanofluidic environment dramatically shortens immunoassay time-to-result through the combined action of efficient mass transfer and short diffusion distances. Here, we report on a fully automated point-of-care in vitro diagnostic platform based on disposable capsule containing nanofluidic sensors in which fluorescent immunoassays are performed. Performances of the system were established with three model assays for ferritin, immunoglobulin E (IgE) and pancreatic stone protein (PSP). The described system has the typical high capture efficiency of nano-confined spaces combined with forced-flow, which induce a constant maximal concentration gradient on the sensor. Remarkably, analytes are detected in zeptomole quantities from a drop of blood. Dose-response curves show that high precision and accuracy are achieved in the clinically relevant assay ranges. Moreover, acc.. View more»
  

  DOI: 10.35248/2157-7439.19.10.536

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