National Clinical Research Center of Kidney Disease, Jinling hospital, Nanjing Medical University, Najing 210002, Jiangsu, China
Da-feng He is currently working as a Professor in the Department of Clinical Research. His research interests includes Medicine. He is serving as an editorial member and reviewer of several international reputed journals. He has successfully completed his Administrative responsibilities. He has authored of many research articles/books related to Medicine.
Research Article
Association of Low Serum Complement 3 with Worse Glomerular Filtration Rate in Patients with IgA Nephropathy Secondary to Psoriasis
Author(s): Da-feng He, Rong Wang, Chun-lei Lu, Shi-jun Li, Chang-hua Liu, Cai-hong Zeng and Zheng Tang*
Objective: Complement system is pivotal in the pathogenesis of psoriasis and IgA Nephropathy (IgAN). Few studies have examined the features of patients with IgAN secondary to Psoriasis (IgAN-Pso). The association of serum complement and renal function is unknown. This study was made to investigate the relationship between serum C3 and glomerular filtration rate in patients with IgAN-Pso.
Methods: In this retrospective cross-sectional study, eighty-five patients with IgAN without evidence of a secondary cause other than psoriasis were enrolled. Patients were divided into two groups: the serum ≥ 0.9 g/L group (n=56) and the serum <0.9 g/L group (n=29). We used CKD-EPI equation to estimate Glomerular Filtration Rate (eGFR) and Empower Stats software to assess the relationship study.
Results: Patients with low se.. View more»