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Avishay Elis
Department of Internal Medicine, Beilinson Hospital, Rabin Medical Centre, Israel
Publications
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Research Article
Apixaban in Elderly Patients with Atrial Fibrillation and Renal Dysfunction: Findings from A National Registry
Author(s): Ela Giladi*, Chen Gurevitz, Robert Klempfner, Ilan Goldenberg and Avishay Elis
Background: We aimed to evaluate the clinical characteristics and outcomes of patients 75 years and older with atrial fibrillation (AF) and renal dysfunction who are treated with apixaban. Methods: A sub analysis of a multicenter prospective cohort registry, where consecutive eligible apixaban or warfarin treated patients with non-valvular AF and renal impairment (eGFR MDRD<60 ml/min/BSA) were registered. All patients were prospectively followed-up for clinical events and dosing adjustments over a mean period of 1 year. The current sub analysis focused on the subjects aged ≥75 years. The primary outcomes were 1 year: mortality, stroke or systemic embolism, major bleeding and myocardial infarction as well as their composite occurrence. Results: In the subjects 75 years or older with renal impai.. View more»