Journal of Carcinogenesis & Mutagenesis

Division of Applied Life Science, Graduate School of Engineering, Sojo University, Kumamoto, Japan

Biography

Yoko Matsumoto is a Professor of Department of Life Sciences at Sojo University, Japan. She received her PhD in Pharmacy from Kyushu University, Japan. She was a Visiting Researcher in Colorado University at Boulder with Prof. Tom Cech. She has received Outstanding Female Researcher Award from the Society of Chemical Engineering, Japan. She is one of Director for Japan Nanomedicine Society and Councilor for Japanese Association for Molecular Target Therapy of Cancer. Her current research interest focuses on trehalose liposomes for therapeutic applications. She has published more than 120 original papers.

Publications

• Research Article   
  Inhibitory Effect of Hybrid Liposomes on the Growth of NP2 Glioma Cells
  Author(s): Yoko Matsumoto*, Keiji Kuwabara and Hideaki Ichihara
  
  The inhibitory activity of hybrid liposomes (HLs), composed of 90 mol% L-α-dimyristoyl-phosphatidylcholine (DMPC) and 10 mol% polyoxyethylene (25) dodecyl ether (C12(EO)25), was investigated in human glioma NP2 cells. HLs with a hydrodynamic diameter below 100 nm persisted for 4 weeks. The inhibitory effect of HLs on the proliferation of NP2 cells was evaluated. Induction of apoptosis in NP2 cells treated with HL was measured through a PI assay and the TUNEL method. HLs caused apoptosis in NP2 cells through the mitochondrial pathway. An increase of AIF protein expression was observed in HL-treated cells. Cellular membrane fluidity of NP2 cells was also increased as revealed by the fluorescence depolarization method. Enhanced HL accumulation in the membrane of NP2 cells was observed. .. View more»
  

  DOI: 10.35248/2157-2518.20.11.344

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