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Yoko Matsumoto
Division of Applied Life Science, Graduate School of Engineering, Sojo University, Kumamoto, Japan
Publications
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Research Article
Inhibitory Effects of Cationic Hybrid Liposomes against Metastasis of Bile Duct Cancer In Vitro and In Vivo
Author(s): Hideaki Ichihara* and Yoko Matsumoto
Cationic Hybrid Liposomes (CL), comprising 87 mol% Dimyristoylphosphatidylcholine (DMPC), 5 mol% polyoxyethylene(21) dodecyl ether (C12(EO)21), and 8 mol% O,O’-ditetradecanoyl-N-(α–trimethylammonioacetyl) diethanolamine chloride (2C14ECl), were prepared using the sonication method. A clear CL solution with a hydrodynamic diameter of 100 nm was maintained for 4 weeks. The inhibitory effects of CL on metastasis were obtained in human bile duct cancer (HuCCT-1) cells in vitro. The inhibitory effects of CL on HuCCT-1 cell migration using scratch assay were obtained. Furthermore, it was observed that CL significantly suppressed the invasion of HuCCT-1 cells and the formation of filopodia on the cell surface in vitro. The anti-invasive effects of CL on HuCCT-1 cells were attributed to the inhibition of MMP2 (Mat.. View more»