Journal of Carcinogenesis & Mutagenesis

Department of Applied Life Science, Graduate School of Engineering, Sojo University, Kumamoto, Japan

Biography

Yoko Matsumoto is a Professor of Department of Life Sciences at Sojo University, Japan. She received her PhD in Pharmacy from Kyushu University, Japan. She was a Visiting Researcher in Colorado University at Boulder with Prof. Tom Cech. She has received Outstanding Female Researcher Award from the Society of Chemical Engineering, Japan. She is one of Director for Japan Nanomedicine Society and Councilor for Japanese Association for Molecular Target Therapy of Cancer. Her current research interest focuses on trehalose liposomes for therapeutic applications. She has published more than 120 original papers.

Publications

• Research Article   
  Trehalose Liposomes Inhibit the Growth of Glioblastoma Cell In vitro and In vivo
  Author(s): Keiji Kuwabara, Hideaki Ichihara and Yoko Matsumoto*
  
  The inhibitory effects of trehalose liposomes (TL) composed of α-D-glycopyranosyl-α-D-glucopyranoside monomyristate and L-α-dimyristoylphosphatidylcholine on the growth of human glioblastoma (U-87MG) cells were evaluated. Induction of apoptosis was observed after fusion and accumulation of TL in U-87MG cell membranes. Increased membrane fluidity of U-87MG cells treated with TL was observed. TL caused apoptosis in U-87MG cells through the activation of mitochondria and apoptosis-inducing factor via a caspase-independent pathway. Tumor weights markedly decreased in orthotopic graft mouse models of glioblastoma (U-87MG) after intravenous administration of TL compared with those in the control group. .. View more»
  

  DOI: 10.35248/2157-2518.21.12.364

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