Journal of Data Mining in Genomics & Proteomics

Henan Key Laboratory of Microbiome and Esophageal Cancer Prevention and Treatment, Luoyang, China

Publications

• Research Article   
  Association of Genetic Polymorphisms in Tumour Necrosis Factor-Alpha (TNF-α- 308G/A) and Interleukin-6 (IL-6-174G/C and IL-6-634C/G) with Lung Cancer Risk: A Meta-Analysis
  Author(s): Yibo Guo, Xinshuai Wang, Xiang Yuan, Yiwen Liu, Wei Sun and Shegan Gao*
  
  The aim of this study was to examine the association of Tumour Necrosis Factor-Alpha (TNF-α) and Interleukin-6 (IL- 6) gene polymorphisms with the risk of developing lung cancer. We searched several electronic databases, including PubMed and Excerpt Medica Database (EMBASE), for a total of 17 studies involving 4,094 cases and 4,988 controls, which were included in a meta-analysis. The effects of three polymorphisms, TNF-α-308G/A, IL-6-174G/C and IL- 6-634C/G, were evaluated. The pooled Odds Ratio (OR) with 95% Confidence Interval (95% CI) was calculated by RevMan software. Heterogeneity was also assessed. Based on our results, we found an association between the TNF-α-308G/A polymorphism and lung cancer risk under the dominant model (GG+GA vs. AA, OR=0.60, 95% CI: 0.40 to 0.89). For the IL-6-174G/C polymorphisms, the pooled ORs (95% CI) of GG/GC vs... View more»
  

  DOI: 10.4172/2153-0602.22.13.247

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