Journal of Microbial & Biochemical Technology

Department of Biomedical Engineering, National University of Singapore, Novena, Singapore

Publications

• Letter   
  Phylogeny of Different Helicobacter pylori Strains could not be Explained by 16S rRNA Gene due to High Similarity in Gene Sequence Across Strains
  Author(s): Wenfa Ng*
  
  Understanding the evolutionary relatedness of different strains of a species helped identify strain-specific differences that may be useful for disease diagnosis and treatment. Typically, such strain level typing would be augmented by molecular assays such as DNA sequencing, and phylogenetic tree analysis. This work utilizes public data on the 16S rRNA gene sequence of different strains of Helicobacter pylori to help plot the phylogenetic tree that describes the evolutionary trajectories of the different strains. Results from multiple sequence alignment reveals high level of conservation in 16S rRNA gene sequence across strains. This then translates into a phylogenetic tree structure that suggests very close evolutionary relationships of the different strains except for one outlier strain. Even in the case of the outlier strain, its evol.. View more»
  

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