PMC/PubMed Indexed Articles
Indexed In
- Academic Journals Database
- Open J Gate
- Genamics JournalSeek
- JournalTOCs
- China National Knowledge Infrastructure (CNKI)
- Scimago
- Ulrich's Periodicals Directory
- RefSeek
- Hamdard University
- EBSCO A-Z
- OCLC- WorldCat
- Publons
- MIAR
- University Grants Commission
- Geneva Foundation for Medical Education and Research
- Euro Pub
- Google Scholar
Useful Links
Share This Page
Open Access Journals
- Agri and Aquaculture
- Biochemistry
- Bioinformatics & Systems Biology
- Business & Management
- Chemistry
- Clinical Sciences
- Engineering
- Food & Nutrition
- General Science
- Genetics & Molecular Biology
- Immunology & Microbiology
- Medical Sciences
- Neuroscience & Psychology
- Nursing & Health Care
- Pharmaceutical Sciences
Wenfa Ng
Department of Biomedical Engineering, National University of Singapore, Novena, Singapore
Publications
-
Research Letter
Preliminary Estimates of the Mutational Frequencies of Individual Genes in SARS-Cov-2 Genome
Author(s): Wenfa Ng*
Evolutionary selection pressure or presence of error-prone polymerase in virus would result in emergence of variants that are more infectious or more deadly. But, different genes encode proteins of different functions in the pathogenic process of the virus, and thus, are subjected to different evolutionary selection pressure. This necessarily leads to different mutational frequencies which have implications for the evolution of the virus, and its associated pathogenic potential. This work sought to determine a preliminary estimate of the mutational frequency of each gene in SARSCoV- 2 genome using 10 assembled genomes deposited in European Nucleotide Archive. Results reveal that five genes are commonly mutated. Specifically, these genes are RNA-dependent RNA polymerase, spike protein, ORF3a , ORF8 and nucleocapsid protein. In particular, RNA-depende.. View more»