Journal of Pharmacovigilance

Department of Pharmacology, Maulana Azad Medical College, New Delhi, India

Publications

• Case Report   
  Amoxicillin /Clavulanic Acid Induced Mixed Hepatocellular-Cholestatic Hepatic Injury- A Rare Case Report
  Author(s): Shreshth Khanna, Vandana Tayal* and Vandana Roy
  
  Amoxicillin is an extended spectrum acid stable bactericidal beta-lactam antibiotic, commonly used in the treatment and prophylaxis of gram positive and negative bacterial infections. Clavulanic acid, a beta-lactamase inhibitor that is often used in conjunction with amoxicillin (co-amoxiclav) prevents the hydrolysis and re-establishes amoxicillin's activity that binds irreversibly to the catalytic site of susceptible beta-lactamases and has good activity against beta-lactamase producing streptococci, staphylococci, Klebsiella pneumonia, H. influenzae and penicillinase-producing anaerobes and is most commonly used for upper respiratory infections, otitis media and sinusitis to broaden its spectrum further and combat resistance. Commonly reported adverse effects of co-amoxiclav include nausea, vomiting, headache, abdominal pain, skin rashes and oral thrush. Few rare and serious adve.. View more»
  

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