Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
Dr. Sonia Anand is a professor in the Department of Medicine, and the Director of the Population Genomics Program, at McMaster. She is also a senior scientist at the Population Health Research Institute at Hamilton Health Sciences. She holds a Canada Research Chair in Ethnic Diversity and Cardiovascular Disease. In 2010, Dr. Anand was named among the top 100 women by the Women’s Executive Network for her accomplishments in research and medicine. Her current research focuses on environmental and genetic determinants of vascular disease in populations of varying ancestral origin, women and cardiovascular disease.
Original Research Article
Venous Return Assist Devices for Intermittent Claudication: A Randomized Controlled Trial Utilizing a Sham Comparator
Author(s): François Caron, Ankit Garg, Eric Kaplovitch, Natasha Aleksova, Barbara Nowacki, Russell de Souza, Binod Neupane, Jeff Ginsberg, Jack Hirsh, John Eikelboom and Sonia S Anand*
Objectives: To determine whether an intermittent mechanical compression device (Venowave) effects walking distance in patients with intermittent claudication as compared to placebo, as well as to review the published literature on the topic. Design: Randomized, cross-over, blinded trial of an intermittent mechanical compression device (Venowave), compared with a sham compression device. Setting: Hamilton Health Sciences, Hamilton, Canada. Participants: 27 patients with severe peripheral limb ischemia, as identified by at least one of: i) ABI<0.4; ii) ACD<200 m (Fontaine stage IIb); iii) toe-brachial index<0.5; or iv) toe pressure<40 mmHg or rest pain due to arterial ischemia. Main Outcome Measures: The primary outcome measure was Absolute Claudication Distance (ACD) while walking on a treadmill. Secondary outcome measures included Initial Claudication Distance (ICD), walk .. View more»