Pharmaceutica Analytica Acta

Department of Chemistry, University of Mysore, Manasagangotri, Mysore, India

Biography

Soma SB. Chikkaswamy works in the Department of Chemistry, University of Mysore, Manasagangotri, Mysore, India. The respected author has specialization in the field of Chemistry.

Publications

• Research Article   
  Quantitative Determination of Brexpiprazole by RP-HPLC Method
  Author(s): Veera S. Pulusu*, Krishna C. Routhu and Soma SB. Chikkaswamy
  
  A stability-indicating RP-HPLC method was established and validated for the determination of Brexpiprazole in bulk drug using C18 column Waters (150 mm×4.6 mm, 5 µm) with a mobile phase containing of 500 mL of 10 mM monobasic Potassium phosphate buffer adjusted pH 2.0 with 85% Orthophosphoric acid and 500 mL of HPLC grade Acetonitrile. The mobile phase was filtered with a 0.45 µm membrane filter and degassed by sonicating for few minutes. The detection was performed at 213 nm using a Photodiode Array Detector at a flow rate of 1.0 mL min-1 and Brexpiprazole was eluted at 2.5 min. with column temperature 30°C. The detector response was generated from the concentration range of 0.01-0.06 mg mL-1 and regression coefficient(r) was 0.999. Brexpiprazole was exposed to stress conditions such as acidic, basic, oxidation, hydrolysis, photolysis and t.. View more»
  

  DOI: 10.35248/2153-2435.19.10.610

  Abstract HTML PDF