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Sivaranjani Devendiran
Department of Pharmaceutics, PSG College of Pharmacy, Coimbatore, Tamilnadu, India
Publications
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Research Article
Permeability Enhancement Approach for Dexamethasone using Niosomal Gel for Treating Keloids
Author(s): Sivaranjani Devendiran* and Veintramuthu Sankar
Background: Niosome are surfactant based vesicular drug delivery system that improves the residence time of drugs by overcoming the inherent anatomical barrier. Dexamethasone is used as an intralesional injection for treating keloids, which is formulated as niosomal gel for the inhibition of keloid fibroblast. This study aimed to formulate the Dexamethasone niosome suspension and the suspension was incorporated into the gel. Niosomal suspension of Dexamethasone was formulated by thin-film hydration method using Tween 20, Span 60, and Tween 80. Tween 80 niosome formulation was optimized using Design of Expert software (DOE). Optimized niosome were characterized for particle size, zeta potential, Atomic Force Microscopy (AFM), entrapment efficiency, in vitro release, cell proliferation studies, and cell permeation studies. The optimized twe.. View more»