Journal of Stem Cell Research & Therapy

Department of Biotechnology, Biotechnology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran

Publications

• Research   
  Paracrine Secretions and Immunological Activities of Human Mesenchymal Stem Cells: The Key Regenerative Factors of Microenvironment
  Author(s): Seyed Mehdi Hoseini, Elham Sadat Hosseini, Pantea Abessi and Fateme Montazeri*
  
  Human Mesenchymal Stem Cells (hMSCs) have immunomodulatory properties, mainly through their paracrine secretions, which contain anti-inflammatory molecules and exosomes. The favourable characteristics of hMSCs in the regeneration of damaged tissues have caused these cells to be considered a therapeutic approach in immune-related diseases. However, the cell therapy approach requires a detailed understanding of the behaviour of hMSCs in the inflammatory microenvironment of target tissues because MSCs may respond differently to this pathological microenvironment compared to normal physiological conditions. In addition, the level of influence that effective mechanisms of hMSCs, including paracrine approaches and cell contact, have on maintaining homeostasis and repairing damaged tissues is a subject of on-going controversy. hMSCs show different characteristics in vitro a.. View more»
  

  DOI: 10.35248/2157-7633.24.14.636.

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