Biochemistry & Analytical Biochemistry

Department of Cancer and Genetics, Cardiff University, Cardiff, United Kingdom

Publications

• Case Study   
  Progressive Decline in the Levels of Six miRNAs from Parents to Children in Autism
  Author(s): Minoo Rassoulzadegan*, Ecmel Mehmetbeyoglu, Zeynep Yilmaz, Serpil Taheri and Yusuf Ozkul
  
  The growing burden of a gradual increase in births of children with autism has placed it at the center of the concerns of major laboratories. We have previously detected a decrease in the levels of six miRNAs (miR-19a-3p, miR-361-5p, miR-3613-3p, miR-150-5p, miR-126-3p, and miR-499a-5p) in parents and their children inherited at a lower level. Here, we suggest that down-regulation of each of these six miRNAs inherited from parents contributes to the development of children with autism. We compare their levels of distribution in each family between the autistic child and siblings. We find that the distribution of levels of these miRNAs in siblings (undiagnosed as autism) is not always higher than in autistic children, but it is at varying levels. These data support a model in which autistic behavior relies on low levels of the six miRNAs expressed in children potentially associated wit.. View more»
  

  DOI: 10.35248/2161-1009.22.11.457

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