Journal of Bioequivalence & Bioavailability

Abbott Laboratories Chile, Huechuraba, Chile

Publications

• Research   
  An Open Label, Balanced, Randomized, Two Treatments, Two Sequences, Two Periods, Crossover, Single Dose, Oral Bioequivalence Study of Femelle 20 (Drospirenone 3 Mg and Ethinyl Estradiol 0.02 Mg) Coated Tablets of Abbott and Yaz® (Drospirenone 3 Mg And Ethinyl Estradiol 0.02 Mg) Coated Tablets of Bayer in Healthy, Adult, Human Female Subjects Under Fasting Condition
  Author(s): Arjun Arumugam O*, Geethalakshmi G, Srinivas G, Kramm Karina, Sasso Jaime, Vergara Sebastian, Ghünter Erich, Salazar Boris, Sosa María del Milagro, Jimenez Julio, Gavino-Gutiérrez Arquímedes M, Lara Claudia and Higuera Maria Juliana
  
  Yaz® Drospirenone and ethinyl estradiol is a Combined Oral Contraceptive (COC). Drospirenone is a spironolactone analogue with anti-mineralocorticoid and anti-androgenic activity. The estrogen in Yaz® is ethinyl estradiol. COCs lower the risk of becoming pregnant primarily by suppressing ovulation. Yaz® is also indicated for the treatment of symptoms of Pre Menstrual Dysphoric Disorder (PMDD) in women who choose to use an oral contraceptive as their method of contraception. The purpose of this study was to evaluate the bioequivalence between Femelle 20 (Drospirenone 3 mg and ethinyl estradiol 0.02 mg) coated tablets of Abbott versus Yaz® (Drospirenone 3 mg and ethinyl estradiol 0.02 mg) coated tablets of Bayer under fasting condition in healthy non-pregnant female subjects. An open label, balanced, randomize.. View more»
  

  DOI: 10.35248/0975-0851.23.15.528

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