Journal of Carcinogenesis & Mutagenesis

Department of Biochemistry and Bioinformatics, Onco-Stem Cell Research Laboratory, School of Sciences, GITAM University, Visakhapatnam, India

Publications

• Review Article   
  Cell-Cell Communications: New Insights in Targeting Tight Junctions through Phytochemicals for Potential Cancer Therapeutic Adjuvants
  Author(s): Santhi Latha Pandrangi*, Prasanthi Chittineedi, Juan Alejandro Neira Mosquera, Sungey Naynee Sánchez Llaguno and Gooty Jaffer Mohiddin
  
  Cancer is a cellular impairment disorder characterized by the loss of cell cycle regulation leading to aberrant cell proliferation. Cell-cell communication plays a crucial role in cell signaling which is highly disrupted in various malignancies. Tight Junctions (TJs) are major proteins that regulate the proper communication. Dysregulation of TJ proteins make these tumor cells more aggressive leading to tumor invasion and metastasis. Hence targeting TJs might be the novel insights in targeting these highly invasive, metastatic tumors. Due to the prohibitive costs of treatments, side effects and development of resistance, the herbal medications comprising bioactive ingredients became more popular for various human ailments. Unfortunately, the importance of natural compounds has significantly reduced due to the development of modern synthetic techniques to formulate drugs. However, the p.. View more»
  

  DOI: 10.35248/2157-2518.22.S33:001

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