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Santhi Latha Pandrangi
Onco-Stem Cell Research Laboratory, GITAM School of Sciences, GITAM Deemed to be University, Visakhapatnam, India
Publications
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Research Article
Concomitant Therapy of Aq. Theobroma Extract and Doxorubicin Reduces Stemness and Induces Ferroptosis in Therapeutic Resistant Cervical Cancer Cells
Author(s): Prasanthi Chittineedi, Santhi Latha Pandrangi*, Gooty Jaffer Mohiddin, Juan Alejandro Neira Mosquera and Sungey Naynee Sánchez Llaguno
Background: Doxorubicin (Dox) is one of the potent antineoplastic drugs currently used as a chemotherapeutic agent for several cancers. Numerous studies suggested that multiple chemotherapeutic cycles with Dox might lead to development of drug resistance and cardiotoxicity in patients leading to poor prognosis, and survival outcome. Present study aims to lower the drug dosage of Dox without altering its antitumor potential. Aqueous Theobroma Extract (ATE) has been reported previously to have several anti-tumor properties and is known to be used as a traditional medicine in the treatment of various diseases without any adverse effects like cardiotoxicity and hepatoxicity. In the present study we demonstrate that ATE when used in combination with Dox exhibited a synergistic antitumor effect, sensitizes therapeutic resistant cervical cancer cells through inducti.. View more»