Journal of Surgery and Anesthesia

Department of Anaesthesiology and Intensive Care, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana

Biography

Dr. Sanjeev Singh is one of the dedicated Professor working in the Department of Anaesthesiology and Intensive Care, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. Dr. Sanjeev Singh has authored of many research articles related to Anesthesia and his research work includes Surgery.

Publications

• Research Article   
  Is Lignocaine Preconditioning Effective to Treat Severe Pulmonary Vasoconstriction Induced by Protamine During Cardiac Surgery?
  Author(s): Sanjeev Singh* and Anbarasu Annamalai
  
  Protamine is a low molecular weight protein fraction (5.5-13.0 kDa) that is rich in basic arginine (67%) and lysine amino acids. They are basic polypeptides that neutralize the strongly negatively charged heparin. This study was aimed to explore the effect of lignocaine preconditioning on protamine-induced pulmonary vasoconstriction, which is used to reverse the effect of heparin during cardiac surgery. This was a prospective, single-centre, double-blind and randomised study performed among eighty paediatric patients of either sex in the age group between 1 to 12 years with acyanotic congenital heart disease, scheduled for elective on-pump cardiac surgery under general anaesthesia. The study participants were divided into four groups: Group A non-pulmonary hypertension+lignocaine preconditioning, group B- non-pulmonary hypertension+normal saline preconditioning, g.. View more»
  

  DOI: 10.35248/2684-1606.21.5.148

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