Department of Anaesthesiology and Intensive Care, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
Dr. Sanjeev Singh is one of the dedicated Professor working in the Department of Anaesthesiology and Intensive Care, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. Dr. Sanjeev Singh has authored of many research articles related to Anesthesia and his research work includes Surgery.
Research Article
Is Lignocaine Preconditioning Effective to Treat Severe Pulmonary Vasoconstriction Induced by Protamine During Cardiac Surgery?
Author(s): Sanjeev Singh* and Anbarasu Annamalai
Protamine is a low molecular weight protein fraction (5.5-13.0 kDa) that is rich in basic arginine (67%) and lysine amino
acids. They are basic polypeptides that neutralize the strongly negatively charged heparin. This study was aimed to explore
the effect of lignocaine preconditioning on protamine-induced pulmonary vasoconstriction, which is used to reverse the
effect of heparin during cardiac surgery. This was a prospective, single-centre, double-blind and randomised study performed
among eighty paediatric patients of either sex in the age group between 1 to 12 years with acyanotic congenital heart disease,
scheduled for elective on-pump cardiac surgery under general anaesthesia. The study participants were divided into four
groups: Group A non-pulmonary hypertension+lignocaine preconditioning, group B- non-pulmonary hypertension+normal
saline preconditioning, g.. View more»