Department of Obstetric and Gynecology, San Martino Hospital,Genoa, Italy
Review Article
The Latest Evidence of Risks and Management of Venous Thromboembolism in Pregnancy: A Comprehensive Review
Author(s): Salvatore Felis*, Beatrice Marchese and Irene Gavini
Venous Thromboembolism (VTE) is a major cause of maternal morbidity and mortality during pregnancy or early
after delivery and it remains a diagnostic and therapeutic challenge. The latest Confidential Enquiry into Maternal
Deaths showed that VTE is now the third leading cause of direct maternal mortality, beside sepsis and hypertension.
In particular the prevalence of VTE has been estimated to be 1 per 1000-2000 pregnancies. The risk of VTE is five
times higher in a pregnant woman than in non-pregnant woman of similar age and postpartum VTE is more common
than antepartum VTE. This review aimed to provide an update of whole current literature on VTE in pregnancy
highlighting the most recent findings in diagnostic and therapeutic strategies, considering in detail risks and benefits
of various techniques and drug classes, for both mother and fetus. Large trials of a.. View more»