Journal of Vaccines & Vaccination

Medical Solution Promotion Department, Medical Solution Segment, LSI Medience Corporation Yokohama, Kanagawa 227-8502, Japan

Biography

Professor Sakiko Sato is affiliated with the Department of Medicine, Hokkaido University, Japan. Sakiko Sato is currently providing services as Professor. Sakiko Sato has successfully completed his Administrative responsibilities. Sakiko Sato has authored many research articles/books related to Medicine, immunology.Her research interests includes Medicine, Immunology,  Vaccine efficacy. Sakiko Sato is serving as an editorial member and reviewer of several international reputed journals.

Publications

• Research Article   
  Purification of Syncytia-Producing Peptide as a Potential Therapeutic Agent for Cancer and Viral Infection
  Author(s): Michiko Koga*, Xiang-Guo Zheng, Manabu Watanabe, Sakiko Sato and Kazuhiro Tanabe
  
  Virus-induced syncytium formation, or cell fusion, has been investigated as a potential therapeutic approach for cancer. HVJ virus infection or transfection of membrane glycoproteins of virions have been known to cause syncytium formation in affected cells. Also, it was known that other enveloped viruses such as Herpes viruses, leukaemia viruses induce cell fusion. However, substances or molecules that directly cause syncytium formation have not been identified to date. Here, we identify a peptide that efficiently induces syncytia and report its structure, as an actionable therapeutic agent for cancer and viral infection. We purified and identified the fusion factor from the exosomes of the cells infected with murine leukaemia virus but not producing viruses by column chromatography, mass spectrometry, and amino acid analyses. We confirmed the peptide purified fro.. View more»
  

  DOI: 10.35248/2157-7560.21.s13.002

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