Journal of Clinical and Medical Sciences

Department of Biotechnology, University of Gujrat, Pakistan

Biography

Sadaf Shamim, belonging to the Department of Biotechnology, interested in the field of Biotechnology, HGPS; Progerin; Lamin A/C; Methylene blue; Early aging; Fibroblasts; CRISPR Cas9; Gene therapy, University of Gujrat, Pakistan

Publications

• Review   
  Treatment Strategies for Toxic Protein Progerin: Hutchinson- Gilford Progeria Syndrome
  Author(s): Sadaf Shamim*
  
  Hutchinson- Gilford Progeria Syndrome (HGPS; MIM 176670) is a rare fatal genetic disorder similar to a rapidly increasing age in symptoms. Aging is the main risk factor for heart diseases. It is becoming more prevalent in our societies. Hutchinson- Gilford Progeria Syndrome is an extremely infrequent inherited disease characterized by too early and fast aging immediately after being born. It a rare autosomal dominant genetic disorder, in 1 to 4 million births, for which there is no known cure. Children with HGPS succumb to myocardial infection and stroke in their teens and die of progressive vascular disease at an average age of 14 years. The average life of a child with HGPS is about 13 years. Some can die young with the disease and others may live longer, even for 20 years. The aim of this review is to understand the various aspects of disease special emphasis on pathophysiology, sy.. View more»
  

  DOI: 10.35248/2593-9947.20.4.116

  Abstract PDF