Journal of Blood Disorders & Transfusion

Damanhour Teaching Hospital, Hematology Unit, Cairo, Egypt

Publications

• Research Article   
  Safety and Efficacy of Early Use of Iron Chelation in Infants and Toddlers with Transfusion-Dependent Thalassemia: A Multicenter Prospective Study
  Author(s): Mohsen Elalfy, Amira Adly*, Amal Elbeshlawy, Mona Hamdy, Tamer Hassan, Mohamed Meabed, Rasha El Ashry, Khalid Elsayeh, Seham Rageb, Mohamed Elshanshoury, Naglaa Shahein, Mahmoud El-Hawy, Gihan Lofty, Saad Shehata, Islam Elghamry, Yasser Wali and Omar Elalfy
  
  Background: There are limited data on the efficacy and safety of oral iron chelators in infants and toddlers and cite the Deferiprone (DFP) and Deferasirox (DFX) label that states that those chelators were not studied in children under the age of 2 and 3 years respectively. The current study was designed to assess the long-term safety and efficacy of DFX and DFP in this young population. Methods: A 2-year prospective multi-center, investigator-initiated non-interventional study of infants and children with TDT after at least 4 blood transfusions, naïve to chelation. The children started either on DFX at a dose of 20 mg/kg/day-25 mg/kg/day or DFP at a dose of 50 mg/kg/day-75 mg/kg/day. Throughout the study all patients were subjected to through history and clinical examination stressing on detailed transfusion data, compl.. View more»
  

  DOI: 10.4172/2155-9864.23.S3.015

  Abstract HTML PDF